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Patients at high risk for mucositis include those undergoing myeloablative therapies for stemcell transplantation, radiation for head and neck cancer, or multicycle chemotherapy regimens. 14 In general, the more intense the chemotherapy treatment, the greater the risk of mucositis; cisplatin, doxorubicin, 5fluorouracil 5FU; bolus more than infusional, methotrexate, melphalan, and cyclophosphamide carry high risks. 4 Patients with poor dental hygiene, poorly fitting dental prostheses trauma, or low WBC counts also may be at higher risk for mucositis.
Perhaps the link with sex and the fact that it is designed to combat a sexuallytransmitted virus are what make the most pernicious slasher lie about Gardasil, that it causes primary ovarian insufficiency, more commonly known as premature ovarian failure POF, so hard to kill for good. Basically, POF is early menopause and usually defined as loss of normal ovarian function before the age of 40. It can and does occur in young women and even teenagers, for whom it is a particularly devastating problem.
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