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McMurray said, but little is known about the cardiovascular effects of diabetes medications in that patient subset because patients with heart failure are typically excluded from clinical trials of antiglycemic agents.

Prevention and treatment of diseases of the cardiovascular system: atherosclerosis, coronary heart disease, hypertension, heart rhythm disturbances.

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In the case of all approved therapeutic agents, the time frame has been extended to cover the 30 years from Jan.

Concomitant use of other DPP-4 inhibitors or glucagon-like peptide 1 agonists was not allowed.

This study also demonstrated that the FDA-approved (2013) SGLT-2 inhibitor canagliflozin ( 12) and the approved HIV protease inhibitor darunavir ( 13) may have cross-activities in renin inhibition as well as their regular approved pharmacological targets, thus potentially repurposing these compounds.

Improved treatment satisfaction and weight-related quality of life with exenatide once weekly or twice daily.

In our efforts to control glucose levels in T2DM patients, efficacy of the treatment in terms of glucose-lowering potential is, however, only one aspect of therapy.

FDA labs discovered various levels of hidden APIs in three tested products, including Diexi, Insupro Forte, and Jiang Tang Yi Huo Su Jiao Nang (translated: Anti-diabetic Pancreatic Capsule).

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Another nanoparticular, paclitaxel (PICN), was approved in India in 2014 as the fourth variation on this drug delivery approach, and two plant-derived agents, omacetaxine mepesuccinate (homoharringtonine) ( 40) and ingenol mebutate ( 41) (as an agent against actinic keratosis, a precancerous condition, that if untreated usually leads to a melanoma), were approved in 2012 by the FDA.

Central augmentation of the incretin system has been shown to protect neuronal cells (neuroprotection), influence neurobehavioral changes (enhanced learning, cognition, spatial orientation) and regulate food and energy intake (weight loss).

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Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: a randomized trial.

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This appears to be the first reported case of acute pancreatitis in a patient receiving vildagliptin, and it supports the possibility that acute pancreatitis may be a rare effect of incretin-based therapy.

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It works by decreasing the amount of sugar that the liver produces and the intestines absorb.

Sitagliptin in combination with a sulfonylurea or insulin has been associated with additive hypoglycemic effects.

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However, a 1-year follow-up study of patients who were initiated on exenatide, sitagliptin, glyburide, or metformin showed the risk of acute pancreatitis to be comparable between the cohorts.

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Adverse effects observed in clinical trials include nausea, hypoglycemia, tremor, headache and dizziness.

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Dipeptidyl peptidase-4 inhibitors in type 2 diabetes may reduce the risk of autoimmune diseases: a population-based cohort study.

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In 2012, the aminolaevulinic acid conjugate Ameluz was approved for photodynamic therapy, and the same year saw the approval of carfilzomib ( 43), the proteasome derivative that evolved from the work of Craig Crews at Yale University.

Yet sitagliptin does have potential advantages over other drugs, as well as known disadvantages and side effects.

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Liver enzyme abnormalities were noted with vildagliptin, mainly in the 100 mg once daily dose that was not a part of the requested registration or PBS restriction.

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