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I have had Polycythemia vera for 25 years. I was started on hydroxyurea two months ago and recently developed severe petechial hemorrhaging. I was admitted to the hospital with a platelet count of 9,000. I received a six pack of platelets and over seven days (being off the medication) my platelet count had climbed to 74,000. As of Sunday, July 5th, it was at 139,000 (off the medication for ten days). I was given the medication to help prevent the POTENTIAL of developing a blood clot. I have managed my Polycythemia vera pretty well without medication for 25 years (I do take baby aspirin) and wish I had never taken this.
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Hydroxyurea made its debut in 1993 at the IX International AIDS Conference in Berlin, when Dr.

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In controlled clinical trials, hydroxyurea has been shown to increase hemoglobin concentrations, decrease transfusion requirements and lessen painful crises in patients with sickle cell disease.

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Over the course of her career she has made major contributions to our understanding of sickle cell phenotypes as well as pioneered new treatment strategies in clinical trials.

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Acute myelocytic leukemia also occurred in a 42-year-old woman with hemoglobin SS who received hydroxyurea for 6 years; no cytogenetic analysis was performed ().

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Refer to the original guideline document and the online supplement (see the "Availability of Companion Documents" field) for discussions of the balance of benefits versus harms of specific interventions recommended for the diagnosis and management of pulmonary hypertension.

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An abbreviation for a chemotherapy combination used to treat some types of acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL).

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The care of patients with sickle cell disease must be longitudinal across the life span, and the difficulties in transitioning care from pediatric to adult settings remain a challenge.

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Hydroxyurea also increases phosphorylation of p38 MAPK in K562 cells ().

The scleral icterus seen in the image of the previous slide is most likely secondary to the elevated circulating levels of bilirubin as a result of an acute hemolytic event (such as an acute vaso-occlusive crisis).

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Recognizing the need to provide practical guidance for common problems that may lie outside of the panel's evidence reviews or available science, in many areas the published evidence was supplemented by the expertise of the panel members, who have many years of experience in managing and studying individuals with SCD.

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Because this poor-prognosis population usually receives palliative treatment, these results could be promising.

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Accordingly, the AABB considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's unique circumstances.

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The 1 article that described long-term follow-up of the MSH participants reported 3 cases of cancer, 2 of which occurred in the hydroxyurea group ().

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Stroke remains a devastating complication of sickle cell disease, affecting approximately 8% of children with a peak age of 8 years.

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For example, his sickle cell anemia study will be held in a clinical center operated by the highly selective and influential National Institutes of Health.

Diagnosis is also possible during pregnancy.

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